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Ongoing Clinical Trials

  • Adolescent CAH Study Adolescent volunteers with classic CAH, ages 12-18, needed for a clinical trial of the investigational compound NBI-77860. Neurocrine Biosciences, Inc. is conducting an open-label, single-dose clinical trial to assess the effect of NBI-77860 on safety measures and hormone levels in adolescent patients with classic, 21-hydroxylase deficiency, congenital adrenal hyperplasia (CAH). This study will be conducted in approximately 15 adolescent females with CAH. Three independent dosing groups of NBI-77860 (approximately 5 patients per group) will be evaluated following single-dose administration of the study drug.
  • Infracort – Current hydrocortisone replacement therapy poses significant challenges especially at low doses where no licensed therapies exist for neonates and infants. A study is underway to assess an immediate-release, oral formulation of hydrocortisone which has been designed specifically for children.
  • NIH Study of Infertility Disorder – researchers are investigating the role of adrenal hormones in polycystic ovary syndrome (PCOS). This study will be conducted by NIH and studies women aged 16 to 24 with PCOS.
  • Participants sought for NIH study of adrenal disorder – Adults who have congenital adrenal hyperplasia, a disorder of the adrenal glands, may be eligible to take part in a study at the National Institutes of Health on the effectiveness of a new pump which delivers missing adrenal hormones in a manner more closely matching their release by the adrenal glands.
  • Phase III Chronocort® Study – Study of efficacy, safety and tolerability of Chronocort® compared with a standard three times daily hydrocortisone replacement regimen in the treatment of adults with congenital adrenal hyperplasia. For more information, contact the CARES office at 866-227-3737
  • Surgical Outcomes Study– This multi-site study will incorporate parents’ ratings of surgical results along with their ratings of their own psychological outcomes and their satisfaction or regret with their medical decisions in order to evaluate outcomes of modern genitoplasty.
  • Survival vs. reproduction in late onset Congenital Adrenal Hyperplasia – study to understand compliance to treatment among late onset congenital adrenal hyperplasia patients, by establishing factors predicting compliance. To identify contexts in which people are more prone to quitting treatment thus help prevent possible health risks, based on evolutionary theory. Simona Geacar.

Other Resources for Clinical Trials